Which immunoglobulin is primarily involved in allergic reactions?

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Multiple Choice

Which immunoglobulin is primarily involved in allergic reactions?

Explanation:
Allergic reactions are driven by IgE antibodies that bind to mast cells and basophils. When a sensitized person encounters an allergen again, the allergen cross-links the IgE already attached to these cells, causing rapid degranulation and release of histamine and other mediators. This mediator surge leads to the classic allergy symptoms. While IgG, IgA, and IgM have important roles in other immune processes, they are not the primary drivers of the immediate allergic response.

Allergic reactions are driven by IgE antibodies that bind to mast cells and basophils. When a sensitized person encounters an allergen again, the allergen cross-links the IgE already attached to these cells, causing rapid degranulation and release of histamine and other mediators. This mediator surge leads to the classic allergy symptoms. While IgG, IgA, and IgM have important roles in other immune processes, they are not the primary drivers of the immediate allergic response.

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